Meet Actors in the Series – Hollywood Life

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Nearly two decades after her wrongful conviction and imprisonment made international headlines, Amanda Knox reclaimed her story on her own terms with Hulu’s limited series The Twisted Tale of Amanda Knox. The 8-episode drama, which wrapped on October 1, 2025, revisited the Meredith Kercher case and the media firestorm that followed, while also exploring Knox’s search for closure and agency. Grace Van Patten led the cast as Knox, earning praise for bringing new perspective to one of the most infamous trials of the 21st century.

Knox, who co-wrote and executive produced the project, emphasized the show’s purpose. “This is not a show about the worst experience of someone’s life,” she told The New York Times ahead of the premiere. “This is the show of a person’s choice to find closure on their own terms and to reclaim a sense of agency in their own life after that agency has been stolen from them.”

Below, get to know the main cast in Hulu’s The Twisted Tale of Amanda Knox and more about the show.

When Do The Twisted Tale of Amanda Knox Episodes Come Out?

The limited series premiered on Hulu on August 20, 2025, with the first two episodes dropping the same day. New episodes were released weekly, and the 8-episode run concluded on October 1, 2025.

Who Is in the Cast of The Twisted Tale of Amanda Knox?

Grace Van Patten: Amanda Knox 

Grace is best known for her performances in Nine Perfect Strangers and Tell Me Lies. In her August 2025 interview with the NYT, the actress explained how she was able to get into character as Knox.

“I was able to go to those places because of how deeply open Amanda was and how deeply vulnerable she was with me,” Van Patten told the publication.

Knox chimed in to note that Van Patten’s performance evolves from Knox’s 20s to her mid-30s.

“We asked her to play the best experiences of my life and the worst experiences of life,” said Knox, now 38. “We asked her to do it in English and Italian.”

Giuseppe De Domenico: Raffaele Sollecito

Giuseppe De Domenico is an Italian actor best known for his performances in Vermiglio and ZeroZeroZero.

Francesco Acquaroli: Giuliano Mignini

Born in in Rome, Italy, Francesco Acquaroli is known for his performances in Suburra: Blood on Rome and Dogman.

Rebecca Wisocky: Cecilia 

Rebecca Wisocky has recently appeared in a slew of television projects, including Brooklyn Nine-Nine, Dopesick, Ghosts and The Sex Lives of College Girls.